New paper in Nature Communications
Congrats to Barbara on her new paper appearing in Nature Communications. Barbara developed together with the group of Andreas Hierlemann a micropillar assay that mimics the mechanical properties of the epithelia.
by
Christine Khammash
Optically moniotring the pillars allows to quantify the forces generated by rounding mitotic epithelial cells. It is observed that the mitotic cells contract the actomyosin cortex and generate pressure to round against epithelial confinement. However, if this confinement is too stiff the rounding cells use these mechanisms to escape the confinement where they can conduct mitosis in an unperturbed manner.
For more information, see the external pageNature Communications articlecall_made.